Hiding in Plain Sight: Formation and Function of Stress Granules During Microbial Infection of Mammalian Cells

Stress granule (SG) formation is a host cell response to stress-induced translational repression. SGs assemble with RNA-binding proteins and translationally silent mRNA. have been demonstrated be both inhibitory viruses, as well being subverted for viral roles. In contrast, the function of during non-viral microbial infections remains largely unexplored. A handful shown result in SG assembly. Nevertheless, large body evidence suggests hosts widespread infection. Diverse stresses caused by microbes their products can activate integrated stress order inhibit translation initiation through phosphorylation eukaryotic factor 2α (eIF2α). This other contexts results assembly, suggesting that assembly general phenomenon review explores bacterial, fungal, protozoan infection potential functions adaptations pathogen.